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Article

Comprehensive Genomic Profiling of Advanced Anal Adenocarcinoma in Japan.

JCO precision oncology - 1 Jan 2026

Ogura Nozomu, Hirano Hidekazu, Shiraishi Kouya, Fujii Hiroyuki, Hirose Toshiharu, Shoji Hirokazu, Okita Natsuko, Takashima Atsuo, Koyama Takafumi, Yonemori Kan, Kato Ken

Abstract excerpt

PURPOSE: Anal adenocarcinoma (AD) is a rare GI malignancy with no established standard treatment. Little is known about genomic alterations (GAs) and their therapeutic implications in advanced anal AD. Here, we compared the genomic profiles of advanced anal AD and advanced rectal AD. METHODS: We retrospectively extracted data from patients with advanced anal or rectal AD who underwent comprehensive genomic...

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Identifiers

PMID: 41538763
DOI: 10.1200/PO-25-00562
PMCID: PMC12834284

Genes

CAT
APC
BRAF
BRCA2
ERBB2
ERBB3
KRAS
MYC
TP53

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