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Article

Whole-exome sequencing identified mutational profiles of squamous cell carcinomas of anus.

Human pathology - 1 Oct 2018

Shin Sun, Park Hyeon-Chun, Kim Min Sung, Han Mi-Ryung, Lee Sung Hak, Jung Seung Hyun, Lee Sug Hyung, Chung Yeun-Jun

Abstract excerpt

Anal squamous cell carcinoma (ASCC), either with human papillomavirus (+) or (-), is a neoplastic disease with frequent recurrence and metastasis. To characterize ASCC genomes, we attempted to disclose novel alterations of ASCC genomes and other genetic features including mutation signatures. We performed whole-exome sequencing and copy number alteration (CNA) profiling for 8 ASCC samples from 6 patients (2 cases...

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Share to Anal Canal
Share to Anus Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers, Tumor

Share to Carcinoma, Squamous Cell

Share to DNA Copy Number Variations

Share to Exome Sequencing

Share to Neoplasm Recurrence, Local

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Source

Identifiers

PMID: 29555573
DOI: 10.1016/j.humpath.2018.03.008

Genes

HRAS
KLF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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