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Article

Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2017

Mouw Kent W, Cleary James M, Reardon Brendan, Pike Jonathan, Braunstein Lior Z, Kim Jaegil, Amin-Mansour Ali, Miao Diana, Damish Alexis, Chin Joanna, Ott Patrick A, Fuchs Charles S, Martin Neil E, Getz Gad, Carter Scott, Mamon Harvey J, Hornick Jason L, Van Allen Eliezer M, D'Andrea Alan D

Abstract excerpt

Purpose: Squamous cell carcinoma of the anal canal (ASCC) accounts for 2% to 4% of gastrointestinal malignancies in the United States and is increasing in incidence; however, genomic features of ASCC are incompletely characterized. Primary treatment of ASCC involves concurrent chemotherapy and radiation (CRT), but the mutational landscape of resistance to CRT is unknown. Here, we aim to compare mutational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27852700
DOI: 10.1158/1078-0432.CCR-16-2017
PMCID: PMC5433927

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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