Article
Comprehensive genomic profiling of 295 cases of clinically advanced urothelial carcinoma of the urinary bladder reveals a high frequency of clinically relevant genomic alterations.
Cancer - 1 Mar 2016
Ross Jeffrey S, Wang Kai, Khaira Depinder, Ali Siraj M, Fisher Huge A G, Mian Badar, Nazeer Tipu, Elvin Julia A, Palma Norma, Yelensky Roman, Lipson Doron, Miller Vincent A, Stephens Philip J, Subbiah Vivek, Pal Sumanta K
Abstract excerpt
BACKGROUND: In the current study, the authors present a comprehensive genomic profile (CGP)-based study of advanced urothelial carcinoma (UC) designed to detect clinically relevant genomic alterations (CRGAs). METHODS: DNA was extracted from 40 µm of formalin-fixed, paraffin-embedded sections from 295 consecutive cases of recurrent/metastatic UC. CGP was performed on hybridization-captured, adaptor ligation-based...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.