Pathogenic alterations in PIK3CA and KMT2C are frequent and independent prognostic factors in anal squamous cell carcinoma treated with salvage abdominoperineal resection.

doi:10.1002/ijc.34781

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Article

Pathogenic alterations in PIK3CA and KMT2C are frequent and independent prognostic factors in anal squamous cell carcinoma treated with salvage abdominoperineal resection.

International journal of cancer - 1 Feb 2024

Hamza Abderaouf, Masliah-Planchon Julien, Neuzillet Cindy, Lefèvre Jérémie H, Svrcek Magali, Vacher Sophie, Bourneix Christine, Delaye Matthieu, Goéré Diane, Dartigues Peggy, Samalin Emmanuelle, Hilmi Marc, Lazartigues Julien, Girard Elodie, Emile Jean-François, Rigault Eugénie, Dangles-Marie Virginie, Rioux-Leclercq Nathalie, de la Fouchardière Christelle, Tougeron David, Casadei-Gardini Andrea, Mariani Pascale, Peschaud Frédérique, Cacheux Wulfran, Lièvre Astrid, Bièche Ivan

Abstract excerpt

The management of anal squamous cell carcinoma (ASCC) has yet to experience the transformative impact of precision medicine. Conducting genomic analyses may uncover novel prognostic biomarkers and offer potential directions for the development of targeted therapies. To that end, we assessed the prognostic and theragnostic implications of pathogenic variants identified in 571 cancer-related genes from surgical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37908048
DOI: 10.1002/ijc.34781

Genes

KMT2C
PIK3CA
TERT
TP53

Provenance

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