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Article

Molecular characterization of squamous cell carcinoma of the anal canal

1 Oct 2021

Abstract excerpt

Background: Squamous cell carcinoma of the anal canal (SCCA) is an uncommon malignancy with limited therapeutic options. Nivolumab and pembrolizumab show promising results in patients with SCCA. Human papillomavirus (HPV)-negative tumors are frequently TP53-mutated (TP53-MT) and often resistant to therapy. Methods: We present a large molecularly-profiled cohort of SCCA, exploring the underlying biology of SCCA,...

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PMID: 34790403
DOI: 10.21037/jgo-20-610

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