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Article

Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations.

The oncologist - 1 Jan 2016

Ali Siraj M, Pal Sumanta K, Wang Kai, Palma Norma A, Sanford Eric, Bailey Mark, He Jie, Elvin Julia A, Chmielecki Juliann, Squillace Rachel, Dow Edward, Morosini Deborah, Buell Jamie, Yelensky Roman, Lipson Doron, Frampton Garrett M, Howley Peter, Ross Jeffrey S, Stephens Philip J, Miller Vincent A

Abstract excerpt

BACKGROUND: Advanced penile squamous cell carcinoma (PSCC) is associated with poor survival due to the aggressiveness of the disease and lack of effective systemic therapies. Comprehensive genomic profiling (CGP) was performed to identify clinically relevant genomic alterations (CRGAs). MATERIALS AND METHODS: DNA was extracted from 40 μm of formalin-fixed, paraffin-embedded sections in patients with advanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26670666
DOI: 10.1634/theoncologist.2015-0241
PMCID: PMC4709208

Genes

EGFR
NOTCH1
BRCA2
CCND1
RICTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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