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Differentiation‐related epigenomic changes define clinically distinct keratinocyte cancer subclasses

1 Sept 2022

Abstract excerpt

Keratinocyte cancers (KC) are the most prevalent malignancies in fair-skinned populations, posing a significant medical and economic burden to health systems. KC originate in the epidermis and mainly comprise basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC). Here, we combined single-cell multi-omics, transcriptomics, and methylomics to investigate the epigenomic dynamics during epidermal...

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PMID: 36121124
DOI: 10.15252/msb.202211073

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