Article
A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA.
DNA repair - 1 May 2016
Babu Vipin, Schumacher Björn
Abstract excerpt
The transcription-coupled repair pathway (TC-NER) plays a vital role in removing transcription-blocking DNA lesions, particularly UV-induced damage. Clinical symptoms of the two TC-NER-deficiency syndromes, Cockayne syndrome (CS) and UV-hypersensitivity syndrome (UVSS) are dissimilar and the underlying molecular mechanism causing this difference in disease pathology is not yet clearly understood. UV-stimulated...
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