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Article

MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO.

Nucleic acids research - 6 Jul 2018

Bianco Julien N, Schumacher Björn

Abstract excerpt

Ultraviolet (UV) induces distorting lesions to the DNA that can lead to stalling of the RNA polymerase II (RNAP II) and that are removed by transcription-coupled nucleotide excision repair (TC-NER). In humans, mutations in the TC-NER genes CSA and CSB lead to severe postnatal developmental defects in Cockayne syndrome patients. In Caenorhabditis elegans, mutations in the TC-NER genes csa-1 and csb-1, lead to...

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Identifiers

PMID: 29788264
DOI: 10.1093/nar/gky404
PMCID: PMC6159517

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