Article
The nucleotide excision repair pathway is required for UV-C-induced apoptosis in Caenorhabditis elegans.
Cell death and differentiation - 1 Jun 2007
Stergiou L, Doukoumetzidis K, Sendoel A, Hengartner M O
Abstract excerpt
Ultraviolet (UV) radiation is a mutagen of major clinical importance in humans. UV-induced damage activates multiple signaling pathways, which initiate DNA repair, cell cycle arrest and apoptosis. To better understand these pathways, we studied the responses to UV-C light (254 nm) of germ cells in Caenorhabditis elegans. We found that UV activates the same cellular responses in worms as in mammalian cells. Both...
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