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Article

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.

Nature genetics - 1 May 2012

Schwertman Petra, Lagarou Anna, Dekkers Dick H W, Raams Anja, van der Hoek Adriana C, Laffeber Charlie, Hoeijmakers Jan H J, Demmers Jeroen A A, Fousteri Maria, Vermeulen Wim, Marteijn Jurgen A

Abstract excerpt

Transcription-coupled nucleotide-excision repair (TC-NER) is a subpathway of NER that efficiently removes the highly toxic RNA polymerase II blocking lesions in DNA. Defective TC-NER gives rise to the human disorders Cockayne syndrome and UV-sensitive syndrome (UV(S)S). NER initiating factors are known to be regulated by ubiquitination. Using a SILAC-based proteomic approach, we identified UVSSA (formerly known...

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Share to Cockayne Syndrome
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

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Source

Identifiers

PMID: 22466611
DOI: 10.1038/ng.2230

Genes

UVSSA
USP7
ERCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.PMID 22466611Read ↗

Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair.Semantic proximity Read ↗

Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.Semantic proximity Read ↗

TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A.Semantic proximity Read ↗

Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.Semantic proximity Read ↗

Prolonged stalling of RNA Polymerase II at DNA damage explains phenotypical differences between Cockayne and UV-sensitive syndromesSemantic proximity Read ↗

Mechanistic insights into the regulation of transcription and transcription-coupled DNA repair by Cockayne syndrome protein B.Semantic proximity Read ↗

The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair.Semantic proximity Read ↗

A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage.Semantic proximity Read ↗

ATP-Dependent Chromatin Remodeler CSB Couples DNA Repair Pathways to Transcription with Implications for Cockayne Syndrome and Cancer TherapySemantic proximity Read ↗

Uncovering the Role of DNA Repair Impairment in UVA-Induced Mutagenesis in Human Xeroderma Pigmentosum Variant Cells.Semantic proximity Read ↗

A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair.Semantic proximity Read ↗

DNA damage response and transcription.Semantic proximity Read ↗

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