Article
A C. elegans model for neurodegeneration in Cockayne syndrome.
Nucleic acids research - 4 Nov 2020
Lopes Amanda F C, Bozek Katarzyna, Herholz Marija, Trifunovic Aleksandra, Rieckher Matthias, Schumacher Björn
Abstract excerpt
Cockayne syndrome (CS) is a congenital syndrome characterized by growth and mental retardation, and premature ageing. The complexity of CS and mammalian models warrants simpler metazoan models that display CS-like phenotypes that could be studied in the context of a live organism. Here, we provide a characterization of neuronal and mitochondrial aberrations caused by a mutation in the csb-1 gene in Caenorhabditis...
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