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Article

COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder.

Bipolar disorders - 1 Aug 2012

Soeiro-de-Souza Márcio Gerhardt, Machado-Vieira Rodrigo, Soares Bio Danielle, Do Prado Carolina Martins, Moreno Ricardo Alberto

Abstract excerpt

OBJECTIVE: The dopaminergic system plays an important role in the prefrontal cortex (PFC) and is believed to mediate cognitive dysfunction (CD) in bipolar disorder (BD). The enzyme catechol-O-methyltransferase (COMT) is involved in the catabolism of dopamine in the PFC, and an association between COMT single nucleotide polymorphisms (SNPs) and BD has been reported. COMT SNPs have also been associated with...

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Identifiers

PMID: 22713126
DOI: 10.1111/j.1399-5618.2012.01030.x

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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