Article
High Frequency of CYP2D6 Ultrarapid Metabolizer Genotype in the Finnish Population.
Basic & clinical pharmacology & toxicology - 1 Sept 2016
Pietarinen Paavo, Tornio Aleksi, Niemi Mikko
Abstract excerpt
CYP2D6 participates in the biotransformation of many commonly used drugs. Large genetic variability in CYP2D6 results in a wide interindividual variability in the response to CYP2D6 substrate drugs. Previous studies have assessed the phenotype and genotype distributions of CYP2D6 in relatively small Finnish population samples. The aim of our study was to investigate the frequencies of CYP2D6 genotypes in a larger...
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