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Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe

29 Jul 2019

Abstract excerpt

CYP2C19 and CYP2D6 are important drug-metabolizing enzymes that are involved in the metabolism of around 30% of all medications. Importantly, the corresponding genes are highly polymorphic and these genetic differences contribute to interindividual and interethnic differences in drug pharmacokinetics, response, and toxicity. In this study we systematically analyzed the frequency distribution of clinically...

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PMID: 31358955
DOI: 10.1038/s41431-019-0480-8

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