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Article

Somatic Mutations and Genetic Variants of NOTCH1 in Head and Neck Squamous Cell Carcinoma Occurrence and Development.

Scientific reports - 1 Apr 2016

Liu Yu-Fan, Chiang Shang-Lun, Lin Chien-Yu, Chang Jan-Gowth, Chung Chia-Min, Ko Albert Min-Shan, Lin You-Zhe, Lee Chien-Hung, Lee Ka-Wo, Chen Mu-Kuan, Hua Chun-Hung, Tsai Ming-Hsui, Chen Yuan-Chien, Ko Ying-Chin

Abstract excerpt

A number of genetic variants have been associated with cancer occurrence, however it may be the acquired somatic mutations (SMs) that drive cancer development. This study investigates the potential SMs and related genetic variants associated with the occurrence and development of head and neck squamous cell carcinoma (HNSCC). We identified several SMs in NOTCH1 from whole-exome sequencing and validated them in a...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27035284
DOI: 10.1038/srep24014
PMCID: PMC4817511

Genes

NOTCH1
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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