Article

The somatic and germline mutational landscape of HPV-negative oral cancer patients with a history of chewing tobacco and betel nut use

2026-01-25

Abstract excerpt

Head and neck cancer (HNC) is highly prevalent in South-Asia, driven by additional region-specific exposures such as chewing tobacco and betel nut. Despite therapeutic advances, five-year survival rate remains around 50-60%, underscoring urgent need to identify novel therapeutic targets and improve disease-free survival. This study was designed to identify both somatic and germline drivers contributing to HNC path...

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Literature Corpus work: 4d4daac4-2f3b-5428-9ac5-7806d7cf35fa
DOI: 10.64898/2026.01.20.26344267

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