Article

Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy

2018-07-09

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is a widely prevalent cancer globally with high mortality and morbidity. We report here changes in the genomic landscape in the development of HNSCC from potentially premalignant lesions (PPOLS) to malignancy and lymph node metastases. Frequent likely pathological mutations are restricted to a relatively small set of genes including TP53, CDKN2A , FBXW7 , FAT1 , NO...

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Literature Corpus work: 52f1ddf1-154a-5626-b1d1-ed4741308435
DOI: 10.1101/365205

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