Article
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1.
Science (New York, N.Y.) - 26 Aug 2011
Agrawal Nishant, Frederick Mitchell J, Pickering Curtis R, Bettegowda Chetan, Chang Kyle, Li Ryan J, Fakhry Carole, Xie Tong-Xin, Zhang Jiexin, Wang Jing, Zhang Nianxiang, El-Naggar Adel K, Jasser Samar A, Weinstein John N, Treviño Lisa, Drummond Jennifer A, Muzny Donna M, Wu Yuanqing, Wood Laura D, Hruban Ralph H, Westra William H, Koch Wayne M, Califano Joseph A, Gibbs Richard A, Sidransky David, Vogelstein Bert, Velculescu Victor E, Papadopoulos Nickolas, Wheeler David A, Kinzler Kenneth W, Myers Jeffrey N
Abstract excerpt
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. To explore the genetic origins of this cancer, we used whole-exome sequencing and gene copy number analyses to study 32 primary tumors. Tumors from patients with a history of tobacco use had more mutations than did tumors from patients who did not use tobacco, and tumors that were negative for human papillomavirus (HPV) had...
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