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Article

Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function.

PloS one - 1 Jan 2016

Shi Xiao, Walter Nicole A R, Harkness John H, Neve Kim A, Williams Robert W, Lu Lu, Belknap John K, Eshleman Amy J, Phillips Tamara J, Janowsky Aaron

Abstract excerpt

Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and β-phenethylamine stimulate the G protein-coupled trace amine-associated receptor 1 (TAAR1). TAAR1 has been implicated in human conditions including obesity, schizophrenia, depression, fibromyalgia, migraine, and addiction. Additionally TAAR1 is expressed on lymphocytes and astrocytes involved in inflammation and...

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Identifiers

PMID: 27031617
DOI: 10.1371/journal.pone.0152581
PMCID: PMC4816557

Genes

TAAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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