Article

Molecular Basis of Human Trace Amine-Associated Receptor 1 Activation

2023-09-07

Abstract excerpt

The human trace amine-associated receptor 1 (hTAAR1, hTA1) is a key regulator of monoaminergic neurotransmission and the actions of psychostimulants. Despite preclinical research demonstrating its tractability as a drug target, its molecular mechanisms of activation remain unclear. Moreover, poorly understood pharmacological differences between rodent and human TA1 complicate the translation of findings from precl...

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Literature Corpus work: 73024157-a3cc-5fc4-ba7a-f67ba5d9a79e
DOI: 10.1101/2023.09.06.556555

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