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Article

A breeding strategy to identify modifiers of high genetic risk for methamphetamine intake.

Genes, brain, and behavior - 1 Feb 2021

Reed Cheryl, Stafford Alexandra M, Mootz John R K, Baba Harue, Erk Jason, Phillips Tamara J

Abstract excerpt

Trace amine-associated receptor 1 (Taar1) impacts methamphetamine (MA) intake. A mutant allele (Taar1m1J ) derived from the DBA/2J mouse strain codes for a non-functional receptor, and Taar1m1J/m1J mice consume more MA than mice possessing the reference Taar1+ allele. To study the impact of this mutation in a genetically diverse population, heterogeneous stock-collaborative cross (HS-CC) mice, the product of an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32424970
DOI: 10.1111/gbb.12667
PMCID: PMC7671946

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