Article
A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.
PloS one - 17 Aug 2010
Li Zhengsheng, Mulligan Megan K, Wang Xusheng, Miles Michael F, Lu Lu, Williams Robert W
Abstract excerpt
BACKGROUND: Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of dopamine and norepinephrine. COMT activity influences cognitive and emotional states in humans and aggression and drug responses in mice. This study identifies the key sequence variant that leads to differences in Comt mRNA and protein levels among mice, and that modulates synaptic function and pharmacological and...
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