Article
Genetic variation in cerebellar nicotinic acetylcholine receptor (nAChR) function impacts efficacy of nicotine and varenicline treatment of alcohol withdrawal-induced motor impairment.
Neuropharmacology - 1 Oct 2026
McLean Nadia A, Greenway Abigail E, Gray Ty L, Stiles Samantha N Shippell, Denton Travis T, Rossi David J
Abstract excerpt
In the U.S., 10% of the population is diagnosed with Alcohol Use Disorder (AUD), and 80% of those individuals also use nicotine, making both substances major public health concerns. AUD is characterized by chronic alcohol (EtOH) consumption, dependence, and withdrawal, sustained by neurological adaptations, such as occurs in the cerebellum. Specifically, in the cerebellum, acute EtOH increases inhibition, but...
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