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Article

Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence

10 Oct 2019

Abstract excerpt

BACKGROUND: Methamphetamine (MA) is a potent agonist at the trace amine-associated receptor 1 (TAAR1). This study evaluated a common variant (CV) in the human TAAR1 gene, synonymous single nucleotide polymorphism (SNP) V288V, to determine the involvement of TAAR1 in MA dependence. METHODS: Participants (n = 106) with active MA dependence (MA-ACT), in remission from MA dependence (MA-REM), with active...

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PMID: 31600226
DOI: 10.1371/journal.pone.0220270

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