Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis

1 May 2011

Abstract excerpt

Chromosomal translocations involving chimeric fusions of the nucleoporin NUP98 protein have often been described in acute myelogenous leukemia (AML). All the fusion proteins have an identical NUP98 N terminus, which contains the GLEBS motif for interaction with the mRNA export factor RAE1 and FG repeats that associate with the transcription factors HDAC1 and p300. It is virtually unknown whether these interaction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Protein Degradation and Inhibitors
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21467841
DOI: 10.4161/cc.10.9.15494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesisPMID 21467841Read ↗

Delineating domains and functions of NUP98 contributing to the leukemogenic activity of NUP98-HOX fusions.Semantic proximity Read ↗

Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype.Semantic proximity Read ↗

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insightsSemantic proximity Read ↗

NUP98 Rearrangements in AML: Molecular Mechanisms and Clinical ImplicationsSemantic proximity Read ↗

Inhibition of CRM1-mediated nuclear export of transcription factors by leukemogenic NUP98 fusion proteins.Semantic proximity Read ↗

The Retinoblastoma Tumor Suppressor Is Required for the NUP98-HOXA9-Induced Aberrant Nuclear Envelope Phenotype.Semantic proximity Read ↗

Mechanistic insights and potential therapeutic approaches for NUP98 -rearranged hematologic malignanciesSemantic proximity Read ↗

CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemiaSemantic proximity Read ↗

NUP98 oncofusions in myeloid malignancies: An update on molecular mechanisms and therapeutic opportunitiesSemantic proximity Read ↗

Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute myeloid leukemiaSemantic proximity Read ↗

NUP98 dysregulation in myeloid leukemogenesis.Semantic proximity Read ↗

The MLL–Menin Interaction is a Therapeutic Vulnerability in NUP98-rearranged AMLSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.