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Article

Inhibition of CRM1-mediated nuclear export of transcription factors by leukemogenic NUP98 fusion proteins.

The Journal of biological chemistry - 21 May 2010

Takeda Akiko, Sarma Nayan J, Abdul-Nabi Anmaar M, Yaseen Nabeel R

Abstract excerpt

NUP98 is a nucleoporin that plays complex roles in the nucleocytoplasmic trafficking of macromolecules. Rearrangements of the NUP98 gene in human leukemia result in the expression of numerous fusion oncoproteins whose effect on nucleocytoplasmic trafficking is poorly understood. The present study was undertaken to determine the effects of leukemogenic NUP98 fusion proteins on CRM1-mediated nuclear export....

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Topics

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Share to Antigens, CD34
Share to Exportin 1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Karyopherins

Share to NFATC Transcription Factors

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Share to ran GTP-Binding Protein

Share to rev Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 20233715
DOI: 10.1074/jbc.M109.048785
PMCID: PMC2871492

Genes

NUP98
HOXA9
DDX10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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