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Article

Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes.

Scientific reports - 31 Mar 2016

Shimabukuro Marilia Kimie, Langhi Larissa Gutman Paranhos, Cordeiro Ingrid, Brito José M, Batista Claudia Maria de Castro, Mattson Mark P, Mello Coelho Valeria de

Abstract excerpt

We characterized cerebral Oil Red O-positive lipid-laden cells (LLC) of aging mice evaluating their distribution, morphology, density, functional activities and inflammatory phenotype. We identified LLC in meningeal, cortical and neurogenic brain regions. The density of cerebral LLC increased with age. LLC presenting small lipid droplets were visualized adjacent to blood vessels or deeper in the brain cortical...

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PMID: 27029648
DOI: 10.1038/srep23795
PMCID: PMC4814830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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