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Cholesterol Metabolism in Aging and Age-Related Disorders

10 Jul 2023

Abstract excerpt

All mammalian cell membranes contain cholesterol to maintain membrane integrity. The transport of this hydrophobic lipid is mediated by lipoproteins. Cholesterol is especially enriched in the brain, particularly in synaptic and myelin membranes. Aging involves changes in sterol metabolism in peripheral organs and also in the brain. Some of those alterations have the potential to promote or to counteract the...

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PMID: 37428605
DOI: 10.1146/annurev-neuro-091922-034237

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