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Article

Targeting Oncogenes into a Defined Subset of Mammary Cells Demonstrates That the Initiating Oncogenic Mutation Defines the Resulting Tumor Phenotype.

International journal of biological sciences - 1 Jan 2016

Holloway Kimberly R, Sinha Vidya C, Bu Wen, Toneff Michael, Dong Jie, Peng Yi, Li Yi

Abstract excerpt

Breast cancers exhibit high intertumoral heterogeneity in genetic alterations as well as histopathological and other phenotypic characteristics. The contribution of the initiating oncogenic mutation to tumor phenotype remains controversial, largely due to the technical difficulties in delivering genetic alterations into well-defined subsets of mammary epithelial cells. To examine how different initiating...

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Source

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Identifiers

PMID: 27019623
DOI: 10.7150/ijbs.12947
PMCID: PMC4807158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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