Article
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America - 23 Dec 2003
Li Yi, Welm Bryan, Podsypanina Katrina, Huang Shixia, Chamorro Mario, Zhang Xiaomei, Rowlands Tracey, Egeblad Mikala, Cowin Pam, Werb Zena, Tan Lee K, Rosen Jeffrey M, Varmus Harold E
Abstract excerpt
Breast cancer is a genetically and clinically heterogeneous disease, and the contributions of different target cells and different oncogenic mutations to this heterogeneity are not well understood. Here we report that mammary tumors induced by components of the Wnt signaling pathway contain heterogeneous cell types and express early developmental markers, in contrast to tumors induced by other signaling elements....
Topics
- Animals
- Cytoskeletal Proteins
- Female
- Genes, myc
- Mammary Neoplasms, Experimental
- Mammary Tumor Virus, Mouse
- Mice
- Mice, Transgenic
- Mutation