At least two well-spaced samples are needed to genotype a solid tumor.

Abstract excerpt

BACKGROUND: Human cancers are often sequenced to identify mutations. However, cancers are spatially heterogeneous populations with public mutations in all cells and private mutations in some cells. Without empiric knowledge of how mutations are distributed within a solid tumor it is uncertain whether single or multiple samples adequately sample its heterogeneity. METHODS: Using a cohort of 12 human colorectal...

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