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Intra-tumoral Heterogeneity of<i>KRAS</i>and<i>BRAF</i>Mutation Status in Patients with Advanced Colorectal Cancer (aCRC) and Cost-Effectiveness of Multiple Sample Testing

2011-01-01

Abstract excerpt

KRAS mutation status is established as a predictive biomarker of benefit from anti-EGFr therapies. Mutations are normally assessed using DNA extracted from one formalin-fixed, paraffin-embedded (FFPE) tumor block. We assessed heterogeneity of KRAS and BRAF mutation status intra-tumorally (multiple blocks from the same primary tumor). We also investigated the utility and efficiency of genotyping a ‘DNA cocktail’ pr...

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Literature Corpus work
5946bb80-b35f-580d-9357-3c7af37cdcbb
DOI
10.1155/2011/393521
Open publication

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