Article
Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages.
Cell host & microbe - 14 Jun 2017
Wong Ching-On, Gregory Steven, Hu Hongxiang, Chao Yufang, Sepúlveda Victoria E, He Yuchun, Li-Kroeger David, Goldman William E, Bellen Hugo J, Venkatachalam Kartik
Abstract excerpt
Clearance of bacteria by macrophages involves internalization of the microorganisms into phagosomes, which are then delivered to endolysosomes for enzymatic degradation. These spatiotemporally segregated processes are not known to be functionally coupled. Here, we show that lysosomal degradation of bacteria sustains phagocytic uptake. In Drosophila and mammalian macrophages, lysosomal dysfunction due to loss of...
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