Article
Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal.
Cell reports - 13 Apr 2021
Sommer Frida, Torraca Vincenzo, Xie Yufei, In 't Veld Aliede E, Willemse Joost, Meijer Annemarie H
Abstract excerpt
Chemotaxis and lysosomal function are closely intertwined processes essential for the inflammatory response and clearance of intracellular bacteria. We used the zebrafish model to examine the link between chemotactic signaling and lysosome physiology in macrophages during mycobacterial infection and wound-induced inflammation in vivo. Macrophages from zebrafish larvae carrying a mutation in a chemokine receptor...
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