Article
The Interplay of Host Lysosomes and Intracellular Pathogens
20 Nov 2020
Abstract excerpt
Lysosomes are an integral part of the intracellular defense system against microbes. Lysosomal homeostasis in the host is adaptable and responds to conditions such as infection or nutritional deprivation. Pathogens such asMycobacterium tuberculosis(Mtb) andSalmonellaavoid lysosomal targeting by actively manipulating the host vesicular trafficking and reside in a vacuole altered from the default lysosomal...
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