The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection

Abstract excerpt

Mycobacterial pathogens are the causative agents of chronic infectious diseases like tuberculosis and leprosy.Autophagy has recently emerged as an innate mechanism for defense against these intracellular pathogens.In vitro studies have shown that mycobacteria escaping from phagosomes into the cytosol are ubiquitinated and targeted by selective autophagy receptors.However, there is currently no in vivo evidence...

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