Article

Gaucher Disease Protects Against Tuberculosis

2022-10-17

Abstract excerpt

Biallelic mutations in the glucocerebrosidase ( GBA1 ) gene cause Gaucher disease, characterized by lysosomal accumulation of glucosylceramide and glucosylsphingosine in macrophages. This and other lysosomal diseases occur with high frequency in Ashkenazi Jews. It has been proposed that the underlying mutations confer a selective advantage, in particular conferring protection against tuberculosis. Here, using a z...

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Literature Corpus work: 40ac2bb7-1aa8-53a2-9cbb-10abac52cce0
DOI: 10.1101/2022.10.16.512394

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