Article

The selective autophagy receptors Optineurin and p62 are both required for innate host defense against mycobacterial infection

2018-09-12

Abstract excerpt

Mycobacterial pathogens are the causative agents of chronic infectious diseases like tuberculosis and leprosy. Autophagy has recently emerged as an innate mechanism for defense against these intracellular pathogens. In vitro studies have shown that mycobacteria escaping from phagosomes into the cytosol are ubiquitinated and targeted by selective autophagy receptors. However, there is currently no in vivo evidenc...

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Literature Corpus work: 4e11a86d-31dc-5b95-8b23-888d1d28a96f
DOI: 10.1101/415463

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