Back to search

Article

Galectin-8 senses phagosomal damage and recruits selective autophagy adapter TAX1BP1 to control <i>Mycobacterium tuberculosis</i> infection in macrophages

2020-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Mycobacterium tuberculosis (Mtb) infects a quarter of the world and causes the deadliest infectious disease worldwide. Upon infection, Mtb is phagocytosed by macrophages and uses its virulence-associated ESX-1 secretion system to modulate the host cell and establish a replicative niche. We have previously shown the ESX-1 secretion system permeabilizes the Mtb-containing phagosome and that a popu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2629327c-655d-55b2-91f1-91ba7c191fdf
DOI
10.1101/2020.06.30.180877
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Galectin-8 senses phagosomal damage and recruits selective autophagy adapter TAX1BP1 to control <i>Mycobacterium tuberculosis</i> infection in macrophagesDOI 10.1101/2020.06.30.180877
Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in MacrophagesSemantic proximity
Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic <i>Mycobacterium tuberculosis</i> infection but not acute infection with multiple intracellular pathogensSemantic proximity
Immunoevasion and immunosuppression of the macrophage by <i><scp>M</scp>ycobacterium tuberculosis</i>Semantic proximity
A genome-wide screen in macrophages defines host genes regulating the uptake of <i>Mycobacterium abscessus</i>Semantic proximity
Mechanisms of immune evasion by Mycobacterium tuberculosis : the impact of T7SS and cell wall lipids on host defensesSemantic proximity
Autophagy protects against high-dose <i>Mycobacterium tuberculosis</i> infectionSemantic proximity
Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial InfectionSemantic proximity
The exploitation of host autophagy and ubiquitin machinery by <i>Mycobacterium tuberculosis</i> in shaping immune responses and host defense during infectionSemantic proximity
Tuberculosis and the art of macrophage manipulationSemantic proximity
Autophagy prevents early proinflammatory responses and neutrophil recruitment during Mycobacterium tuberculosis infection without affecting pathogen burden in macrophagesSemantic proximity
ATG7 in innate immune cells is required for host defense against nontuberculous mycobacterial pulmonary infectionsSemantic proximity
Autophagy as an innate defense against mycobacteriaSemantic proximity
Select a neighboring publication to make it the new centre.