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Article

Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency.

Blood - 23 Jun 2016

Theocharides Alexandre P A, Lundberg Pontus, Lakkaraju Asvin K K, Lysenko Veronika, Myburgh Renier, Aguzzi Adriano, Skoda Radek C, Manz Markus G

Abstract excerpt

The pathogenesis of acquired myeloperoxidase (MPO) deficiency, a rare phenomenon observed in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), is unknown. MPO is a glycoprotein (GP) chaperoned by calreticulin (CALR) in the endoplasmic reticulum. Mutations in CALR are frequently found in patients with myelofibrosis (MF) and essential thrombocythemia (ET) with nonmutated Janus...

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Source

Identifiers

PMID: 27013444
DOI: 10.1182/blood-2016-02-696310

Genes

MPO
CALR
EPX
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency.PMID 27013444Read ↗

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Quality control in the endoplasmic reticulum: lessons from hereditary myeloperoxidase deficiency.Semantic proximity Read ↗

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The role of calreticulin mutations in myeloproliferative neoplasms.Semantic proximity Read ↗

CALR frameshift mutations in MPN patient-derived iPS cells accelerate maturation of megakaryocytesSemantic proximity Read ↗

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