Article
Impact of missense mutations on biosynthesis of myeloperoxidase.
Redox report : communications in free radical research - 1 Jan 2000
Nauseef W M, McCormick S, Goedken M
Abstract excerpt
We have examined the biosynthesis of normal and mutant forms of myeloperoxidase (MPO) in order to gain insights into the critical features of normal biogenesis of MPO. The expression of wild-type and mutant forms of MPO in a stably transfected cell line devoid of endogenous MPO as well as in established human promyelocytic cell lines has allowed understanding of several features of MPO biosynthesis. It is clear...
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