Article
Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.
Blood - 10 Mar 2016
Chachoua Ilyas, Pecquet Christian, El-Khoury Mira, Nivarthi Harini, Albu Roxana-Irina, Marty Caroline, Gryshkova Vitalina, Defour Jean-Philippe, Vertenoeil Gaëlle, Ngo Anna, Koay Ann, Raslova Hana, Courtoy Pierre J, Choong Meng Ling, Plo Isabelle, Vainchenker William, Kralovics Robert, Constantinescu Stefan N
Abstract excerpt
Mutations in the calreticulin gene (CALR) represented by deletions and insertions in exon 9 inducing a -1/+2 frameshift are associated with a significant fraction of myeloproliferative neoplasms (MPNs). The mechanisms by which CALR mutants induce MPN are unknown. Here, we show by transcriptional, proliferation, biochemical, and primary cell assays that the pathogenic CALR mutants specifically activate the...
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