Quality control in the endoplasmic reticulum: lessons from hereditary myeloperoxidase deficiency.

doi:10.1016/s0022-2143(99)90200-7

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Article

Quality control in the endoplasmic reticulum: lessons from hereditary myeloperoxidase deficiency.

The Journal of laboratory and clinical medicine - 1 Sept 1999

Nauseef W M

Abstract excerpt

The optimal level of oxygen-dependent microbicidal activity in human neutrophils depends on the generation of highly toxic products, including hypochlorous acid, by hydrogen peroxide in the presence of chloride anion and the neutrophil granule protein myeloperoxidase (MPO). The biosynthesis of MPO is normally restricted to the promyelocytic stage of myeloid development and includes N-linked glycosylation, heme...

Topics

Amino Acid Sequence
Calcium-Binding Proteins
Calnexin
Calreticulin
Cell Line
Endoplasmic Reticulum
Genotype
Humans
Models, Biological
Neutrophils
Peroxidase
Point Mutation
Protein Folding
Ribonucleoproteins
Transfection

Source

Open in PubMed

Identifiers

PMID: 10482305
DOI: 10.1016/s0022-2143(99)90200-7

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