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Article

Quality control in the endoplasmic reticulum: lessons from hereditary myeloperoxidase deficiency.

The Journal of laboratory and clinical medicine - 1 Sept 1999

Nauseef W M

Abstract excerpt

The optimal level of oxygen-dependent microbicidal activity in human neutrophils depends on the generation of highly toxic products, including hypochlorous acid, by hydrogen peroxide in the presence of chloride anion and the neutrophil granule protein myeloperoxidase (MPO). The biosynthesis of MPO is normally restricted to the promyelocytic stage of myeloid development and includes N-linked glycosylation, heme...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10482305
DOI: 10.1016/s0022-2143(99)90200-7

Genes

MPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Myeloperoxidase as an Active Disease Biomarker: Its Recent Biochemical and Pathological PerspectivesSemantic proximity Read ↗

T47D Cells Expressing Myeloperoxidase Are Able to Process, Traffic and Store the Mature Protein in Lysosomes: Studies in T47D Cells Reveal a Role for Cys319 in MPO Biosynthesis that Precedes Its Known Role in Inter-Molecular Disulfide Bond Formation.Semantic proximity Read ↗

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