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Article

CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytes

22 Oct 2021

Abstract excerpt

Calreticulin (CALR) mutations are driver mutations in myeloproliferative neoplasms (MPNs), leading to activation of the thrombopoietin receptor and causing abnormal megakaryopoiesis. Here, we generated patient-derived CALRins5- or CALRdel52-positive induced pluripotent stem cells (iPSCs) to establish an MPN disease model for molecular and mechanistic studies. We demonstrated myeloperoxidase deficiency in...

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PMID: 34678208
DOI: 10.1016/j.stemcr.2021.09.019

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