Article
Calreticulin mutations affect its chaperone function and perturb the glycoproteome.
Cell reports - 22 Nov 2022
Schürch Patrick M, Malinovska Liliana, Hleihil Mohammad, Losa Marco, Hofstetter Mara C, Wildschut Mattheus H E, Lysenko Veronika, Lakkaraju Asvin K K, Maat Christina A, Benke Dietmar, Aguzzi Adriano, Wollscheid Bernd, Picotti Paola, Theocharides Alexandre P A
Abstract excerpt
Calreticulin (CALR) is an endoplasmic reticulum (ER)-retained chaperone that assists glycoproteins in obtaining their structure. CALR mutations occur in patients with myeloproliferative neoplasms (MPNs), and the ER retention of CALR mutants (CALR MUT) is reduced due to a lacking KDEL sequence. Here, we investigate the impact of CALR mutations on protein structure and protein levels in MPNs by subjecting primary...
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