Article

CALR frameshift mutations in MPN patient-derived iPS cells accelerate maturation of megakaryocytes

2021-07-05

Abstract excerpt

Calreticulin (CALR) mutations are driver mutations in myeloproliferative neoplasms (MPNs), leading to activation of the thrombopoietin receptor, and causing abnormal megakaryopoiesis. Here, we generated patient-derived CALR ins5- or CALR del52-positive induced pluripotent stem (iPS) cells to establish a MPN disease model for molecular and mechanistic studies. We demonstrated myeloperoxidase deficiency in CD15+ g...

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Literature Corpus work: 2cda0539-83ef-54b1-932f-71fc41dd48c1
DOI: 10.1101/2021.07.05.451130

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