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Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

25 Nov 2015

Abstract excerpt

Frameshift mutations in the calreticulin (CALR) gene are seen in about 30% of essential thrombocythemia and myelofibrosis patients. To address the contribution of the CALR mutants to the pathogenesis of myeloproliferative neoplasms, we engrafted lethally irradiated recipient mice with bone marrow cells transduced with retroviruses expressing these mutants. In contrast to wild-type CALR, CALRdel52 (type I) and, to...

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PMID: 26608331
DOI: 10.1182/blood-2015-11-679571

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