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Article

The role of calreticulin mutations in myeloproliferative neoplasms.

International journal of hematology - 1 Feb 2020

Araki Marito, Komatsu Norio

Abstract excerpt

Unique frameshift mutations in the calreticulin (CALR) gene, which encodes an endoplasmic reticulum (ER)-localized molecular chaperone, have been identified in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF), which are subgroups of myeloproliferative neoplasms (MPNs). In this review, we discuss the current understanding of the consequences of these mutations with regard to...

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Identifiers

PMID: 31848992
DOI: 10.1007/s12185-019-02800-0

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